Antidiabetic effects of catharanthus roseus, azadirachta indica, allium sativum and glimepride in experimentally diabetic induced rat. Pdf chemical constituents and pharmacological activities. We proposed that inhibition of alphaglucosidase is the mechanism by which garlic produces its antidiabetic effect. Antidiabetic and hypolipidaemic properties of ginger. Oct 26, 2007 garlic allium sativum, which is a common cooking spice and has a long history as a folk remedy, has been reported to have antidiabetic activity. The anticancer properties of fresh allium sativum extracts, aged allium sativum, allium sativum oil, and a number of specific organosulfur compounds was assessed. Determination of antidiabetic activity in allium cepa onion tissue cultures s m kelkar, g s kakli and v a bapat2 radiation biology division i and nuclear agriculture and biotechnology division2 bhabha atomic research centre, mumbai 400 085, india received 12 may 2000. Antidiabetic and antioxidant properties of methanolic. The antidiabetic activity of each individual spice is well documented, but their e.
Allium sativum aqueous extracts produced a dose dependent significant reduction in blood glucose levels, total serum lipids and total serum cholesterol levels when compared with that of the. Phytomedicine 2006 624629 antidiabetic effect of garlic allium sativum l. Turkeychopped garlic tc has antimicrobial activity against 17 bacteria. Ashrafuzzaman sapon, monokesh kumer sen abstract in the last few years, there has been an exponential growth in the field of herbal medicine and gaining. It has been reported to possess several biological properties including anticarcinogenic, antioxidant, antidiabetic, renoprotective, antiatherosclerotic, antibacterial, antifungal, and antihypertensive. Allium sativum, normoglycemic, hypoglycemic, glibenclamide.
For the assessment of antidiabetic activity, two dose level were chosen in such a way that. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf. Shamim hossain, naim hassan, biplab kumar dash, md. Materials and methods plant material garlic bulbs allium sativum linn. Many of the agents used as antidiabetic are either expensive or have side effects. The pharmacological activity of garlic allium sativum and its related compounds. Garlic allium sativum and ginger zingiber officinale attenuate structural nephropathy progression in streptozotocininduced diabetic rats. Species from north east india with special reference to their pharmacological activities borborah k, dutta b and borthakur sk research scholar, department of botany, gauhati university, stateassam, country india. Many studies have reported that the inhibitory action of allium sativum juice on fungi may be due to the formation of hydrogen bonds between the hydroxyl group of phenolic compounds and the active sites of the target enzymes yin and tsao et al. In vitro antidiabetic evaluation of allium sativum l.
Preparaton of standard dilutions of garlic extract the dilution were prepared by using ethylene glycol which. Antidiabetic herbal drugs and polyherbal formulation used. Antibacterial activity of allium sativum against staphylococcus aureus in vitro 347 was 27% at a wave length of 580 nanometer, while the light transmittance was 100% for nutrient broth used to prepare the bacteria jassim, 2003. Plant material was subjected to the extraction preparation by soxhlet apparatus by using various solvents such as aqueous, ethanol, chloroform, petroleum ether and hexane. Phytochemical and in vitro antidiabetic activity of psidium. Antidiabetic potential of two medicinal plants used in. Antidiabetic herbal drugs and polyherbal formulation used for. Pleiotropic garlic allium sativum in the treatment of diabetes mellitus and its complications patil t. The result showed that the anticancer activity of allium sativum was due to dose and temporalrelated changes involved in the cancer process. In addition, the activities of two garlic samples, one from taskopru, kastamonu, turkey tr, and the other from china cn, are also compared. Herbal plant onion used for antidiabetic allium sativum.
The aim of this study was to examine if garlic produces its antidiabetic activity by inhibiting alphaglucosidase. Pdf studies on the antidiabetic activity of allium. In this sense, nickavar and yousefian 15 reported alphaamylase inhibitory potential of four allium species a. Leguminoseae, liliaceae, moraceae and rosaceae are the major antidiabetic plant families. Antidiabetic activity the tissue extract of seedling parts and callus of allium cepa l. Diabetes has become a leading killer disease in recent years.
Pleiotropic garlic allium sativum in the treatment. Garlic allium sativum supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients. Experimentally, various medicinal plants have been found to have antidiabetic activity 5. The garlic bulbs were cleaned properly and deskinned and weighed. Antihyperglycemic mechanisms of allium sativum, citrus. Pdf antidiabetic effect of garlic allium sativum l.
Antidiabetic activity was determined by glucose entrapment potential of allium sativum. This effect is thought to be due to increased hepatic metabolism, increased insulin release from pancreatic beta cells andor insulin sparing effect. Garlic allium sativum supplementation with standard. From ethnobotanical information it has been reported that about 800 traditional plants may carry antidiabetic potential, among all of them momordica charantia, pterocarpus marsupium, allium sativum, azadirachta indica, vinca. Antidiabetic and antioxidant properties of methanolic extract. Researchers are now turning their attention to phytotherapy as a viable alternative in the treatment of hyperglycemia. Antimicrobial screening of garlic allium sativum extracts. An open labelled prospective comparative study reported on type 2. Anticancer, antiviral, antidiabetic, antifungal and phytochemical.
In vitro antidiabetic activity of cardiospermum halicacabum leaves extracts by stalin. Pdf studies on the antidiabetic activity of allium sativum. Phytochemical evaluation and pharmacological screening of. Pleiotropic garlic allium sativum in the treatment of. The present study was carried out to evaluate the antidiabetic activity of vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. Allium sativum is widely used as a spice in cameroon and has been investigated for its antimalarial activity. Antidiabetic effect of combined spices of allium sativum. Several plants are used in folk medicine for their hypoglycemic activity and they were investigated using different experimental methods. Determination of antidiabetic activity in allium cepa. Currently available antidiabetic drugs mainly target the. A brief overview of the activities of the concerned species has been presented below. Introduction antidiabetic drugs treat diabetes mellitus by lowering glucose levels in the blood. Antidiabetic herbal drugs and polyherbal formulation used for diabetes. The aim of this study was to examine the inhibition of.
The present investigation includes the preliminary screening of phytochemicals and evaluation of in vitro antidiabetic activity of psidium guajava leaves extracts. Phytochemical screening and antibacterial and antifungal. Studies on the antidiabetic activity of allium sativum garlic aqueous extracts on alloxaninduced diabetic albino rat article pdf available in pharmacologyonline 20102. Garlic, a member of the liliaceae family, is a common food for flavour and spice. The metabolic syndrome is a common problem worldwide and includes abdominal obesity, hypertension, dyslipidemia, and hyperglycemia disorders. Antidiabetic activity of vinca rosea extracts in alloxan. Pdf studies on the antidiabetic activity of allium sativum garlic. In the present study, oral administration of garlic extract 0.
Diabetes, garlic, hypoglycaemic activity, hypolipidaemic activity, proteinuria. The antidiabetic activity of each individual spice is well documented, but their effect when combined is unknown. Mechanisms by which some plants with antihyperglycemic effects reduce postprandial hyperglycemiaare not fully elucidated. Hypoglycemic activity of eeas in streptozotocininduced mice. Antidiabetic and hypolipidaemic properties of garlic allium. Antidiabetic and hypolipidaemic properties of garlic. In vitro antioxidant activity and in vivo hepatoprotective activity of aqueous extract of allium cepa bulb in ethanol. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of cardiospermum halicacabum. The result revealed all tested extract of allium sativum show anthelmintic activity in a dose dependent manner. The antidiabetic effect of onion and garlic in experimental diabetic rats. Studies on the antidiabetic activity of allium sativum garlic aqueous extracts on alloxaninduced diabetic albino rat. However, there is no general agreement on the use of garlic for antidiabetic purposes, primarily because of a lack of scientific evidence from human studies and inconsistent data from animal studies.
Potential antidiabetic herbal medicines html full text. Suvagiya 5 faculty of pharmaceutical sciences, pacific university 1, udaipur, rajasthan, india. Garlic allium sativum supplementation improves respiratory health but has increased risk of lower hematologic values in horses. Clinically, it has been evaluated for lowering blood. Diabetes, garlic, hypoglycaemic activity, hypolipidaemic activity, proteinuria introduction garlic allium sativum is one of the most popular herbs used worldwide to reduce various risk factors associated with cardiovascular diseases. In this aspect, the study was carried out to hypolipidemic effect of the fruit husk of this plant on evaluate the antidiabetic and hypolipidemic activity of alloxaninduced diabetes have so far been undertaken. Shaban and muslim ali department of biological sciences, faculty of science, kuwait university, kuwait. Read antidiabetic effect of garlic allium sativum l. It leads to insulin resistance and the development of diabetes mellitus or cardiovascular disease. Garlic allium sativum is one of the most popular herbs. Comparison of antimicrobial activity of allium sativum.
Oral administrations of the garlic extract significantly decreased serum glucose, total cholesterol, triglycerides, urea, uric acid, creatinine, ast and alt levels, while increased serum insulin in diabetic rats but not in normal rats p antifungal activity against anthracnose fungi, dampingoff fungi, and rhizopusnigricans. The present research evaluated the antidiabetic effects and antioxidant activity of the methanolic extract of the supplement powders developed from three food ingredients including drumsticks leaves moringa oleifera, garlic allium sativum and cinnamon cinnamomum verum with different percentages to determine the antidiabetic and. Allium cepa, allium sativum, aloevera, cajanus cajan, coccinia indica, caesalpinia bonducella, ficus. Medicinal plants with potential antidiabetic activity a. Garlic allium sativum linn, a member of liliaceae family has been used in different cultures as foodstuffs and medicine.
The presence study was undertaken to evaluate anthelmintic activity of aqueous extract of allium sativum, against indian earthworm. The methanolic whole plant extract at high dose 500 mgkg exhibited significant antihyperglycemic activity than whole plant extract at low dose 300 mgkg in diabetic rats. Allium sativum garlic has been documented to exhibit antidiabetic, hypotensive, and hypolipidemic properties. This study was designed to investigate some action mechanisms of extracts from stem bark of citrus sinensis, seeds of persea americana and bulbs of allium sativum including in vitro inhibition of. Holy basil,biter gourd,neem used for antidiabetic mechanism of action of herbal antidiabetics the antidiabetic activity of herbs depends upon variety of mechanisms. Nov 24, 2006 read antidiabetic effect of garlic allium sativum l. Comparison of antimicrobial activity of allium sativum cloves. Diabetes mellitus was induced in 54 out of a total of 63. Thanks to these studies, natural glycosidase inhibitors have been discovered and tested for their activity, 14. Garlic allium sativum, which is a common cooking spice and has a long history as a folk remedy, has been reported to have antidiabetic activity. An update 1mohd iqbal yatoo, 2archana saxena, 3arumugam gopalakrishnan, 4mahmoud alagawany and 5kuldeep dhama 1sherekashmir university of agricultural sciences and technology of kashmir, shalimar, 190025 srinagar, jammu and kashmir, india.
Evaluation of antidiabetic, antihyperlipidemicand hepatoprotective effects of allium sativum linn. Antidiabetic and hypolipidaemic properties of garlic allium sativum in streptozotocininduced diabetic rats martha thomson, zainab m. Pdf chemical constituents and pharmacological activities of. Pdf evaluation of antidiabetic, antihyperlipidemicand. The antidiabetic effect of garlic ethanolic extract allium sativum l. Antidiabetic and hypolipidemic activity of punica granatum. Effect of ethanolic extract of allium sativum bulbs on. A comparison was made between the action of garlic extract and glibenclamide 600 microgkg, the known antidiabetic drug. Homidan, 2005 and stz induced rats which showed significant antidiabetic activity. The various kinds of phytochemicals were detected and then in vitro antidiabetic activity of p. Allium sativum garlic, zingiber officinale ginger and capsicum frutescens cayenne pepper are common dietary spices also traditionally used in the treatment of various diseases including diabetes mellitus. The study reveals the presence of phytochemicals such as carbohydrate, tannin, flavonoids, phenols etc.
Promising antidiabetic drugs, medicinal plants and herbs. Garlic belonging to family liliaceae is a well know medicinal plant. Gabon has remarkable biodiversity and rich cultural traditions of plant use. R1, patil s2, patil a3, patil st4 1department of pharmacology bharati medical college and hospital sangli, maharashtra, india. Antidiabetic and hypolipidaemic properties of garlic allium sativum. Phytochemical evaluation and pharmacological screening of antiparkinsons activity of allium 2 this research work was conducted to evaluate the efficacy of an ethanolic extract of allium sativum in the treatment of haloperidol induced catalepsy, for antiparkinson activity. Garlic allicin, a sulfurcontaining compound is responsible for its pungent odour and it has been shown to have significant hypoglycemic activity. Aged garlic extract, ajo, alli sativi bulbus, allium, camphor of the poor, clove garlic, nectar of the gods, poor mans treacle, rust treacle, stinking rose1. Anticancer, antiviral, antidiabetic, antifungal and. Traditional medicines derived from medicinal plants are used by about 60% of the worlds population.
The hypoglycaemic effects could represent a protective 2 mechanism against the development of hyperglycaemia common in diabetes mellitus. List and structures of some of the sulfurcontaining compounds isolated from allium sativum. The antidiabetic effects of allium species including garlic, a. Phytochemical and in vitro antidiabetic activity of. The most active plants are allium sativum, gymnema sylvestre, citrullus colocynthis, trigonella foenum greacum, momordica charantia and ficus bengalensis. The antidiabetic activity of herbs depends upon variety of mechanisms. Allium sativum international journal of medical and health research.